Posted 10 April 2013 - 03:08 AM
Thank you Wurzel Bagman! Your report is a crystal distallation of my own experiences using high-dose Piracetam. There is nothing like the superb clarity, energy, visuals and becoming God - it's call the God Molecule or God Particle for that reason. If you find that even the optimal 30g/day isn't working like it used to, do realize that even while Piracetam is truly the most powerful neural accelerator, it is also the weakest racetam to restore actual energy generation. So Piracetam barely 'pays' for all the brain speedup and depthup it causes. As you age the energy equation tilts and eventually you may run into fatigue. In that case you can add Oxiracetam (about 1g OXI / 4g PIR). Oxiracetam has a higher quantum level than Piracetam and boosts mitochondrial energy conversation capability higher than any dose of Piracetam can. I call it PerOxiClear - the best possible mix of PIR/OXI and overall the best stack I have ever made. However, none of the other racetams have PIR's accelerant feature - they are quiet in nature but provide other benefits. I am still taking 5g x 6 per day Piracetam but I always stack on top of it a truly powerful mitochondrial energy restorer. For only the purpose of enhancing mitochondrial output (anti-brain-fatigue) and according to my tests the racetams listed in order of decreasing power are: 1. Pramiracetam 2. Oxiracetam 3. Aniracetam 4. Piracetam Sunifiram is not a racetam but it's more powerful than those listed above for energy restoration. I have tested Coluracetam but stacked with Piracetam and Pramiracetam due to circumstances so I cannot tell its effect alone.
Posted 10 April 2013 - 03:50 AM
As for saturation dosing, a recent study found 4.8g to be optimal so I dose at even five grams. And for 'useful life' which means how long it lasts before any detectable signs of dropoff - three hours for all racetams except Aniracetam: two hours for that one. Thus we now have the success-without-excessive-wallet-drainage formula for Piracetam: 5g once each 3 hours all day long. For me that means six doses per day totalling 30g Piracetam which is my current regimen. I buy 2kg Piracetam every other month. And for the alternate months I buy Piracetam's double: the higher-energy racetam which will provide for Piracetam's mitochondrial gap and also as secondary benefits their improved visual/procognitive effects. For the last six months Piracetam's dancing partner has been Oxiracetam and lately, Pramiracetam. Finally I have moved up yet again: 15mg doses of Sunifiram complement the Piracetam thus preventing eventual fatigue. I also notice that stacking Piracetam with any other racetam prevents the angry bitchiness that randomly occurs with Piracetam alone after sufficient months of use.
7 years ago (2015)
Piracetam & PhosphatidylSERINE
It is well-known both by scientific study and user reports that Piracetam is not only dependent on Adrenal function to produce its most excellent effects - but critically - it also executes massive intervention on the Adrenals.
Studies: Dependence on Adrenal function:
Adrenalectomy, corticosteroid replacement and their importance for drug-induced memory-enhancement in mice http://www.ncbi.nlm.nih.gov/pubmed/1314083
Aldosterone receptors are involved in the mediation of the memory-enhancing effects of piracetam http://www.ncbi.nlm.nih.gov/pubmed/2149831
Blockade of the nootropic action of piracetam-like nootropics by adrenalectomy: an effect of dosage http://www.sciencedirect.com/science/article/pii/S0166432889800981
Elevated corticosteroid levels block the memory-improving effects of nootropics and cholinomimetics http://www.ncbi.nlm.nih.gov/pubmed/1410129
Involvement of a steroidal component in the mechanism of action of piracetam-like nootropics http://www.ncbi.nlm.nih.gov/pubmed/2137359
Mechanism of Action for the Racetams: Mineralocorticoid Receptors (MR) https://www.reddit.com/r/Nootropics/comments/2eam1l/mechanism_of_action_for_the_racetams/
Piracetam facilitates long-term memory for a passive avoidance task in chicks through a mechanism that requires a brain corticosteroid action http://www.ncbi.nlm.nih.gov/pubmed/9749752
Piracetam modifies morphine and related drug-induced elevation of serum corticosterone concentration in rats http://www.ncbi.nlm.nih.gov/pubmed/6650196
The effects of nootropics on memory: new aspects for basic research http://www.ncbi.nlm.nih.gov/pubmed/2690149
PhosphatidylSERINE is NOT PhosphatidylCHOLINE which is a cheap and common component of Soy Lecithin. PS is a rather expensive supplement.
"In mammals, phosphatidylserine is produced by base-exchange reactions with phosphatidylcholine and phosphatidylethanolamine."
These reactions are dependent on:
Sufficient dietary supply of PhosphatidylCHOLINE.
Correct Genetics to execute the conversion.
A healthy liver unburdened by Alcohol, other Toxins, pre-existing Damage.
There is NO metabolic path which converts Alpha-GPC, Choline Salts [Citrate, Bitartrate, etc.] to PS. Those who take these Choline supplements miss the entire converted production of the key & necessary PS. Alpha-GPC is a ripoff. Many who take Alpha-GPC with PIR or other Racetams report worsened brain fog / fatigue. Worse, supplementation with these 'dry' Cholines likely downregulated many enzymes responsible for conversion of PC & PE to PS. The body is naturally-evolved to expect PC & PE in food sources in unitary ratios with Choline because they come naturally bound together. Only natural Lecithin contains the Phosphatidyls - both Choline and some Serine - that can end up elevating the body's internal supply of PS. Egg Yolk contains PS but it's a different form that has failed in a study on brain function improvement which also found that improvement when animals were fed Soy PS & Bovine Brain PS: Cognition-enhancing properties of subchronic phosphatidylserine (PS) treatment in middle-aged rats: comparison of bovine cortex PS with egg PS and soybean PS http://www.ncbi.nlm.nih.gov/pubmed/10501292 Key summary: "The performance of rats treated with E-PS did not deviate from that of vehicle-treated rats. On the basis of the present study, it was concluded that S-PS, but not E-PS, may have comparable effects on cognition when compared with BC-PS." Composition of Soybean Lecithin.pdf http://naldc.nal.usda.gov/download/26685/PDF Soybean Lecithin contains 5.9% PS and also contains: PhosphatidylCHOLINE: 19-21% PhosphatidylETHANOLAMINE: 8-20% Both of which are converted by the human Liver to PS. Layman's Article: How Phosphatidylserine Blocks Cortisol for Insomnia, Sleep and Weight Loss http://nootriment.com/phosphatidylserine-cortisol/ Studies Most Important Study: The effects of phosphatidylserine on endocrine response to moderate intensity exercise Abstract & Full HTML Text: http://www.jissn.com/content/5/1/11/ Free Full PDF: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503954/pdf/1550-2783-5-11.pdf Key Results: "Mean peak cortisol concentrations and area under the curve (AUC) were lower following PS (39 ± 1% and 35 ± 0%, respectively) when compared to placebo (p < 0.05). PS increased AUC for testosterone to cortisol ratio (184 ± 5%) when compared to placebo (p < 0.05)." Key Figure (2): http://www.jissn.com/content/5/1/11/figure/F2 Second Most Important Study: The influence of phosphatidylserine supplementation on mood and heart rate when faced with an acute stressor Abstract: http://www.ncbi.nlm.nih.gov/pubmed/11842886 "There have been previous reports that supplements of phosphatidylserine (PS) blunted the release of cortisol in response to exercise stress and that it improved mood. The present study extended these observations by considering whether PS supplementation influenced subjective feelings of stress and the change in heart rate when a stressful mental arithmetic task was performed. In young adults, with neuroticism scores above rather than below the median, the taking of 300mg PS each day for a month was associated with feeling less stressed and having a better mood. The study for the first time reports an improvement in mood following PS supplementation in a sub-group of young healthy adults." Third Most Important Study: Effect of phospholipid on aldosterone biosynthesis by a cytochrome P-450(11) beta-reconstituted system Abstract: http://www.ncbi.nlm.nih.gov/pubmed/6525204 "Effect of phospholipid on aldosterone synthesis catalyzed by a cytochrome P-450(11)beta-reconstituted system was examined. Corticosterone was incubated with P-450(11)beta in the presence of phosphatidylcholine, phosphatidylethanolamine, cardiolipin, phosphatidylinositol, or phosphatidylserine." "These phospholipids stimulated the rate of aldosterone- and 18-hydroxycorticosterone-synthesis, although the mode of stimulation by neutral phospholipids was different from that by acidic phospholipids." "In the presence of a phospholipid mixture containing the lipids in the same molar ratios as found in adrenocortical mitochondria, the rate of production of aldosterone increased 10-fold over the rate without the lipids, and that of 18-hydroxycorticosterone increased 3-fold. The maximal synthetic rates of aldosterone and 18-hydroxycorticosterone were 2 and 5 nmol/nmol P-450/min, respectively." The Muscarinic receptor system - which Piracetam is able to restore the density of by up to 30% in aged mice - is also restored by PhosphatidylSERINE. There is a connection. This is not just a random coincidence: Age-Associated Changes of Muscarinic Cholinergic and N-Methyl-D-Aspartate Receptors in the Mouse Brain - Reconstitution by Phosphatidylserine Treatment http://link.springer.com/chapter/10.1007/978-3-642-85789-8_3 Chronic treatment with phosphatidylserine restores muscarinic cholinergic receptor deficits in the aged mouse brain http://www.sciencedirect.com/science/article/pii/019745809290007K All this theory is not enough without Human tests to confirm. There is only one online report of a Human test of PIR + PS combined and it is positive: Longecity: Piracetam non-responders [Page 1: Post 9]: http://www.longecity.org/forum/topic/34864-piracetam-non-responders/#entry361421 LIB: "Through my experience I had piracetam work for me after I started taking Phosphatidylserine to blunt cortisol. Excess cortisol makes all of your hormones less available at normal levels. I started taking Phosphatidylserine because I had excess cortisol through the stress of chelating mercury, and dealing with yeast. I can reasonably confirm that Phosphatidylserine has lowered my cortisol because I need less, sometimes no thyroid medication. I know I need thyroid when I start to get cold, I don't get cold very often now, suggestion thyroid hormone is more available to my body. Also, a month or so after Phosphatidylserine, I started gaining muscle with no excercise or diet changes. Excess cortisol can increase muscle breakdown, and slows muscle growth (simplified). Phosphatidylserine has been great for me in and of itself, but now Piracetam has nice effects for me as well." One result is not enough for me so I will check to verify. I will be testing 600mg/Day PhosphatidylSERINE combined with Piracetam in a week's time. PIR doses will be first 3.3g then 5.5g x 6 / Day. I will also be testing Soy Lecithin @ 13g/Day to compare results. For those who have lost PIR's effects or who never received them: try PS @ a decent dose - 600+ mg/Day - and lay off other Adrenal stressors. Caffeine & stimulants, late bedtimes, stress.
Sherlockian_Holmes ·5 yr. ago·edited 5 yr. ago
Thank you for your response - that's beautiful. I would've loved to speak with him over the phone. What I saw in him was at times beautiful but at other times deeply troubled - especially during some of his more manic phases. I always took it with a grain of salt and tried to redirect the conversation to something else. I don't doubt that he was a most gentle soul and that he simply enjoyed playing the hard-ball persona online every now and then. I did see pictures of him and his beautiful desk. I remember he was very proud of it. I remember feeling very inspired by his level of self-discipline and organization level back in the day. Certainly not the ordinary 'mentally ill' person that most people would perhaps imagine and assume given his depictions on his online persona. We had some great moments together, that's for sure. Especially during my piracetam phase where we basked in the euphoria together speaking of the intricate details of piracetams mechanism of action (most of which is obviously unconfirmed and it was never the panacea that he set it out to be). I saw a lot of his hypomanic tendencies in myself, the flowery language, the need for self-expression in poetry and for wildly divergent way of thinking. I still do all those things and have kept my Spirit alive for lack of a better word. We used to talk a lot about the 'Assemblage Point' from Castenada's books and I tried to convince him that the Warrior's path was something that could actually be traversed if he wanted and had the courage to - but he was so set in his ways, thought that he had already 'cracked' the key and knew the answer. What was certain was that his 'Way' did not bring supramundane bliss, heightened awareness, deep compassion, wisdom and an understanding of the world at large and I had to leave him behind. I found my own path and tried to share things with him that might change his view. In a way, I respect his decision to commit suicide because he came to the conclusion based on his own philosophical framework. Many philosophers came to a similar conclusion, e.g. Camus' meant that the most important question was, Should I kill myself?. I personally think their way is deeply erroneous, but I won't go into that here. All of this does not change the fact that I would've wished that he could've turned around and seen the beauty in the world, in other people, and most of all, himself. Because if he could've realized that he has a far greater potential than any of the thoughts that kept percolating in his mind about this and that, he might have brought himself great happiness and peace. That said I cannot claim to understand the man fully - he is a bit of an enigma, but I hope that he found a way of making peace with reality before he bid his farewell until next time.